Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers

An automated method of performing radiosynthesis using a device having a plurality of reactor assemblies, each reactor assembly of the plurality being moveable in a vertical and horizontal direction;

• a plurality of disposable cassettes disposed above each of the plurality of reactor assemblies, each disposable cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the disposable cassette;
• a reagent and gas handling robot disposed above the plurality of disposable cassettes;
• and a control system configured to control the movement of the reactor assemblies and the reagent and gas handling robot, the method comprising:
• moving a reactor vial contained in a first reactor assembly vertically against one or more of the sealed and unsealed gaskets of a first disposable cassette and performing one or more of the following operations on a radiosynthesis reagent or precursor contained in the reactor vial:
• addition, evaporation, reaction;
• moving a reactor vial contained in a second reactor assembly vertically against one or more of the sealed and unsealed gaskets of a second disposable cassette;
• transferring the radiosynthesis reagent or precursor to a second disposable cassette and into the reactor vial contained in the second reactor;
• and
• performing one or more of the following operations on a radiosynthesis reagent or precursor contained in the reactor vial contained in the second reactor:
• addition, evaporation, reaction.