Method for the production of a form of administration of a medicament
AssigneeGrüNenthal GmbH
InventorsElisabeth Arkenau-Marić, Johannes Bartholomäus, Dieter Schateikis, Kai-Uwe Ustorf
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Abstract
The present invention relates to a method for producing a medicament dosage form which consists of at least one piece which in each case comprises at least one medicament and at least one additive, the medicament and the additive being mixed and extruded from a die as a strand and the strand being cut into pieces of precise weight. The invention additionally relates to a device.
Claims14
A method for producing a medicament dosage form which consists of one or more pieces which in each case comprises at least one medicament and at least one additive, said method comprising (i) mixing the at least one medicament and the at least one additive to form a pasty mixture, (ii) extruding an extrudate consisting of the pasty mixture from a die as a strand, (iii) calibrating a cross-section of the strand, and thereafter (iv) measuring the cross-section of the strand, (v) determining a cross-sectional area of the strand, (vi) calculating a length of the strand to be severed on a basis of a concentration of an active ingredient in the strand and the cross-sectional area determined after the calibrating of the cross-section of the strand, (vii) cutting the strand into one or more pieces of said length and, as a result, predetermined weight, and (viii) producing said medicament dosage form directly from said one or more pieces of said length without further steps being taken for compliance with the predetermined weight.
A method for producing a medicament dosage form, said dosage form consisting of one or more pieces, said one or more pieces comprising at least one medicament and at least one additive, said method comprising (i) mixing the at least one medicament and the at least one additive to form a mixture, (ii) extruding the mixture from a die as a strand, (iii) buffering the strand between a first and a second drawing out means, (iv) calibrating a cross-section of the strand, and thereafter (v) measuring the cross-section of the strand, (vi) determining a cross-sectional area of the strand, (vii) calculating a length of the strand to be severed on a basis of a concentration of an active ingredient in the strand and the cross-sectional area determined after the calibrating of the cross-section of the strand, (viii) cutting the drawn out strand into one or more pieces of said length and, as a result, predetermined weight, and (ix) producing the medicament dosage form directly from said one or more pieces without further steps being taken for compliance with the predetermined weight.
Dependencies are inferred from the claim text.