Systems and methods for detecting nitric oxide
AssigneeAobiome LLC
InventorsJames Heywood, David R. Whitlock
Life of this patent
Estimating the term…
Abstract
A system and method is provided for detection at least one of nitrite (NO2), nitric oxide (NO), nitrogen dioxide (NO2), and other nitrogen oxides (NOx) on a substrate, such as skin. According to one aspect, a diagnostic device for measuring a concentration of at least one of nitrite (NO2), nitrogen dioxide (NO2), nitric oxide (NO), and other nitrogen oxides (NOx) on a substrate comprises a patch comprising at least one chemical compound capable of reacting with the at least one of nitrite, nitrogen dioxide, nitric oxide, and other nitrogen oxides to provide an indicator.
Claims28
A diagnostic device for measuring a concentration of at least one of nitrite (NO2−), nitrogen dioxide (NO2), nitric oxide (NO), and other nitrogen oxides (NOx) on a skin surface, the diagnostic device comprising:
- a patch comprising:
- at least one chemical compound capable of reacting with the at least one of nitrite, nitric oxide, nitrogen dioxide and other nitrogen oxides to provide an indicator,
- a hydrophobic microporous membrane on a first surface of the patch configured to block liquid flow and capable of allowing gas to diffuse and react with the at least one chemical compound, and
- a component comprising an adhesive adjacent to the hydrophobic microporous membrane on the first surface of the patch for securing the device to the skin surface.
A method for measuring a concentration of at least one of nitrite (NO2−), nitrogen dioxide (NO2), nitric oxide (NO), and other nitrogen oxides (NOx) on a skin surface, the method comprising steps of:
- securing to the skin surface a patch comprising at least one chemical compound to react with the at least one of nitrite, nitrogen dioxide, nitric oxide, and other nitrogen oxides and provide an indicator and a hydrophobic microporous membrane configured to block liquid flow and allow gas to diffuse and react with the at least one chemical compound, the patch being secured such that the hydrophobic microporous membrane faces the skin surface;
- periodically monitoring the indicator over a predetermined period of time while the patch is secured to the skin surface to provide at least one measurement;
- and
- comparing the at least one measurement to a known value to provide the concentration of the at least one of nitrite (NO2−), nitrogen dioxide (NO2), nitric oxide (NO), and other nitrogen oxides (NOx).
Dependencies are inferred from the claim text.