Compression connection

A system for the automated compression connection of fluidic components comprising:

• receiving hardware comprising a conduit having an exit opening with a first mating surface of a compression connection and configured to align an insert placed therein;
• an interchangeable plug-and-play consumable insert configured for automated connection and comprising a conduit having an entry opening with a second mating surface of the compression connection;
• a drive force mechanism;
• and
• at least one mechanical support, wherein the drive force mechanism and the at least one mechanical support are each located in the receiving hardware, wherein the insert placed therein is disposed between the at least one mechanical support and the drive force mechanism, and wherein the drive force mechanism is configured to apply a substantially axial drive force opposed by the at least one mechanical support to align and compress the first and second mating surfaces together and create a leak-resistant seal at the compression connection between the insert and the receiving hardware, such that the system provides automated alignment and sealing of the insert.