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US 10,072,276 B2Granted
Genetically engineered yeast cell having increased NADPH production, method of increasing NADPH level in yeast cell, method of preparing yeast cell, and method of producing lactate using yeast cell
AssigneeSamsung Electronics Co., Ltd.
InventorsYukyung Jung, Kwangmyung Cho, Jinha Kim, Soonchun Chung
Life of this patent
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Abstract
Provided is a genetically engineered yeast cell having increased NADPH production, a method of increasing a NADPH level in a yeast cell, a method of preparing the genetically engineered yeast cell, and a method of producing lactate using the genetically engineered yeast cell.
Claims8
A genetically engineered yeast cell, wherein the genetically engineered yeast cell comprises:
- a genetic modification that increases the activity of ZWF1 as compared to a parent yeast cell without the genetic modification;
- and an exogenous polynucleotide encoding a polypeptide that converts pyruvate to lactate;
- wherein the yeast cell has increased lactate production compared to a parent cell.
A method of increasing the level of lactate in a yeast cell, the method comprising
- overexpressing zwf,
- and introducing into the yeast cell an exogenous polynucleotide encoding a gene encoding a polypeptide that converts pyruvate to lactate.
Dependencies are inferred from the claim text.