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US 10,072,150 B2Granted
Methods and materials for the production of monomers for nylon-4/polyester production
AssigneeInvista North America S.A R.L.
InventorsAlex Van Eck Conradie, Adriana Leonora Botes
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Abstract
This document describes biochemical pathways for producing 4-hydroxybutyrate, 4-aminobutyrate, putrescine or 1,4-butanediol by forming one or two terminal functional groups, comprised of amine or hydroxyl group, in a C5 backbone substrate such as 2-oxoglutarate or L-glutamate.
Claims16
A non-naturally occurring method of producing 1,4-butanediol, said method comprising
- [1] enzymatically converting 4-hydroxybutyrate to 4-hydroxybutanal using a carboxylate reductase (EC 1.2.99.6), and
- [2] enzymatically converting 4-hydroxybutanal to 1,4-butanediol using an alcohol dehydrogenase (EC 1.1.1.1, EC 1.1.1.2, EC 1.1.1.21, or EC 1.1.1.184).
Dependencies are inferred from the claim text.