Method for preparing optically active carbonyl compound

A method for preparing an optically active carbonyl compound, the method being characterized by and comprising the following steps:

• conducting asymmetric catalytic reaction to obtain the optically active carbonyl compound under catalysis of chiral amine salt and transition metal catalysts, with hydrogen and catalytic amount of dihydropyridine compound as hydrogen source, using α, β-unsaturated aldehydes or α, β-unsaturated troponoid compounds;
• wherein the structures of the α, β-unsaturated aldehydes or α, β-unsaturated troponoid compounds are as shown in formula (I):
• the structure of the optically active carbonyl compound is as shown in formula (II):
• wherein in formulas (I)˜(II), R1, R2 and R3 are independently selected from hydrogen, halogen, alkyl, heteroaryl, alkoxy or acylamino, wherein acylamino refers to substituents containing —CONH— or —NHCO—, and R1 is different from R2;
• the structures of the chiral amine salt are as shown in formula (IV) or (V):
• R4 is selected from substituted or unsubstituted alkyl, the alkyl refers to alkyl containing ether or polyether, alkyl containing ester or polyester, alkyl containing acylamino or polyamide, or polymer chain alkyl containing mixture of ether, ester and acylamino, wherein acylamino refers to substituents containing —CONH— or —NHCO—;
• X means solidified acid;
• * means asymmetric carbon atom.