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US 10,064,417 B2Granted
Milk filtration devices and methods for filtering
AssigneeJanssen Pharmaceutica NV
InventorsThomas M DiMauro, Kevin Wildenhaus
Life of this patent
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Abstract
A method of cleaning mother's milk, involving ex vivo contacting mother's milk having an initial concentration of an antidepressant therein with a solid substrate (preferably a porous substrate) adapted to remove the antidepressant from the milk to produce a cleansed milk product having a reduced concentration of the antidepressant.
Claims18
A method of cleaning mother's milk, comprising the step of:
- a) ex vivo contacting mother's milk having an initial concentration of an antidepressant therein with a solid substrate adapted to remove free antidepressant from the milk to produce a cleansed milk product having a reduced concentration of the antidepressant representing a reduction of at least 30% from the initial concentration of the antidepressant in the mother's milk, wherein the contacting step comprises contacting mother's milk with immobilized liposomes having an acidic core.
A method of cleaning mother's milk, comprising the step of:
- a) passing mother's milk having an initial concentration of an antidepressant therein through a filter to produce a filtrate having a reduced concentration of the antidepressant, wherein the filter comprises immobilized liposomes having an acidic core.
A method of cleaning mother's milk, comprising the step of:
- a) ex vivo contacting mother's milk having an initial concentration of an antidepressant therein with immobilized liposomes having an acidic core to produce a cleansed milk product having a reduced concentration of the antidepressant.
A method of cleaning mother's milk, comprising the step of:
- a) passing mother's milk having an initial concentration of an antidepressant therein through a filter to produce a filtrate having a reduced concentration of the antidepressant, wherein the filter is a porous matrix disposed within a breast pump, wherein the porous matrix is selected from the group consisting of:
- i) immobilized liposomes having an acid core wherein the liposomes are tethered together via an avidin-biotin tether;
- ii) polymer-coated liposomes having an acid core immobilized on mucoadhesive beads;
- iii) polymer-coated liposomes having an acid core that are sintered together;
- and
- iv) polymer microspheres having an aqueous acid core.
3 more elements
Dependencies are inferred from the claim text.