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US 10,059,746 B2Granted
Methods of improving vaccine immunogenicity
AssigneeUniversity of Iowa Research Foundation
InventorsGail Bishop, Tony Vanden Bush
Life of this patent
Estimating the term…
Abstract
The present invention provides a process called “Immune Banking” that enhances vaccine efficacy by exploiting existing humoral responses. The process involves tagging new antigens with molecular markers recognized by an existing antibody response. This recognition of the tagged vaccine components enhances adaptive immune responses to the new vaccine.
Claims7
A compound comprising at least one antigen covalently linked to an antibody-recognition epitope (ARE), wherein the ARE is a VP-1 epitope of polio virus of about 11-28 amino acids in length comprising IPALTAVETGA (SEQ ID NO:
- 1) or ALTAVETGAT (SEQ ID NO:
- 3), wherein the antigen is further conjugated to an antibody to form an antibody:antigen complex and wherein the antigen is an infectious agent antigen or a cancer antigen.
Dependencies are inferred from the claim text.