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US 10,058,605 B2Granted
Vaccine combinations
AssigneeBharat Biotech International Limited
InventorsKrishna Murthy Ella, Kandaswamy Sumathy
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Abstract
Vaccine combinations which comprise at least two or more of the following antigens: DTap-HEV-HepB-HPV suitable for administration in humans. A number of variations in the combination of these antigens have been disclosed that is suitable for concomitant administration. The methods of preparing the vaccine combinations are disclosed. Nucleic acids encoding the antigens, as well as methods for their production and use are provided.
Claims18
A combination vaccine composition comprising:
- (i) a diphtheria toxoid, D’;
- (ii) a tetanus toxoid, ‘T’;
- (iii) pertussis antigens ‘aP’;
- (iv) recombinant human papillomavirus L1 antigens of HPV16 and HPV18;
- and
- (v) a chimeric fusion protein comprising an HPV L2 epitope in fusion with Hepatitis E ORF2 (HEV ORF2) protein wherein the chimeric fusion protein is expressed as virus like particles.
3 more elements
Dependencies are inferred from the claim text.