Back to results
US 10,058,548 B2Granted
Abuse-proofed dosage form
AssigneeGrüNenthal GmbH
InventorsElisabeth Arkenau-Maric, Johannes Bartholomaeus, Heinrich Kugelmann
Life of this patent
Estimating the term…
Abstract
The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.
Claims29
An abuse-proofed dosage form, in the form of a tablet, which is not in multiparticulate form, thermoformed by extrusion without discoloration comprising:
- i) one or more opioids (A),
- ii) at least 30% by weight, based on the weight of the dosage form, of polyalkylene oxide (C) with a molecular weight of at least 0.5 million g/mol,
- iii) optionally at least one wax (D), and
- iv) a film coating,
- wherein the extrusion is performed at a temperature from the softening point of the polyalkylene oxide up to about 185° C. and the dosage form exhibits a breaking strength of at least 500 N.
2 more elements
Dependencies are inferred from the claim text.