Compositions for delivery of drug combinations
AssigneeCelator Pharmaceuticals, Inc.
InventorsPaul Tardi, Troy Harasym, Murray Webb, Clifford Shew, Andrew Janoff, Lawrence Mayer, Marcel Bally
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Abstract
Compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents, such as antineoplastic agents, are useful in achieving non-antagonistic effects when combinations of drugs are administered.
Claims20
A pharmaceutical composition for parenteral administration, comprising particulate delivery vehicles having associated therewith at least a first antineoplastic agent and a second antineoplastic agent, wherein said first and second agents are in a mole ratio which exhibits a non-antagonistic cytotoxic or cytostatic effect in an in vitro assay, over at least 20% of the concentration range over which the fraction of cells affected is 0.2-0.8;
- and wherein said first and second agents are associated with the delivery vehicles to maintain said non-antagonistic ratio in the blood for at least one hour after administration,
- wherein said delivery vehicles comprise
- liposomes, and/or
- lipid micelles, and/or
- block copolymer micelles, and/or
- polymer microparticles, and/or
- polymer nanoparticles, and/or
- polymer lipid hybrid systems, and/or
- derivatized single chain polymers, and
- wherein the composition comprises one or more additional therapeutic agents.
Dependencies are inferred from the claim text.