Back to results
US 10,053,423 B2Granted
Radioiodinated compounds
AssigneeNUtech Ventures
InventorsStephen DiMagno, Bao Hu
Life of this patent
Estimating the term…
Abstract
This disclosure relates to reagents and methods useful in the synthesis of aryl iodines, for example, in the preparation of iodine labeled radiotracers. The reagents and methods provided herein may be used to access a broad range of compounds, including aromatic compounds, heteroaromatic compounds, amino acids, nucleotides, and synthetic compounds.
Claims19
A method for making a compound of Formula (1):
- Ar2—*I 1
- wherein:
- Ar2 is an aryl or heteroaryl ring system;
- and
- I* is a radioactive isotope of iodine;
- wherein the radioactive isotope of iodine has a specific activity of at least about 1 mCi/mg;
- the method comprising:
- (a) reacting a mixture comprising a compound M*I, wherein M is a counter cation, and compound of Formula (2):
- wherein:
- Ar1 is an aryl or heteroaryl ring system that is electron-rich as compared to Ar2;
- Y is a leaving group;
- and
- Ar2 is as defined above;
- and
- (b) heating the reaction mixture from step (a).
12 more elements
A method for making a compound of Formula (1)
- Ar2—*I 1
- wherein:
- Ar2 is an aryl or heteroaryl ring system;
- and
- *I is a radioactive isotope of iodine;
- wherein the radioactive isotope of iodine has a specific activity of at least about 1 mCi/mg;
- the method comprising heating a compound of Formula (3):
- wherein:
- Ar1 is an aryl or heteroaryl ring system that is electron-rich as compared to Ar2;
- and
- Ar2 is as defined above.
8 more elements
Dependencies are inferred from the claim text.