Treprostinil derivatives and compositions and uses thereof

A pharmaceutical composition comprising a compound of Formula (II):

• wherein:
• —O—Z—CO2H is
• —O-heteroalkyl-CO2H, —O-cyclyl-CO2H, —O—CH2-cyclyl-CO2H, —O-cyclyl-CH2—CO2H, or —O—CH2-cyclyl-CH2—CO2H, each of which may optionally be substituted,
• wherein:
• cyclyl- is -cycloalkyl-, -heterocyclyl-, -aryl- or -heteroaryl-;
• R7 and R8 in each occurrence independently are hydrogen, C1-C6 alkyl or C3-C6 cycloalkyl, or R7 and R8 and the carbon atom to which they are connected form a C3-C6 cycloalkyl ring;
• and
• n is an integer from 1 to 10;
• with the proviso that —O—Z—CO2H is not
• and does not contain a sugar moiety;
• or a pharmaceutically acceptable salt, solvate, hydrate, clathrate, polymorph or stereoisomer thereof, and one or more pharmaceutically acceptable excipients or carriers, wherein the pharmaceutical composition is formulated for administration of the compound of Formula (II) to a subject for therapeutic use.