Compositions comprising electrohydrodynamically obtained fibres for administration of specific doses of an active substance to skin or mucosa

Electrospun fibers prepared by electrospinning a composition comprising (i) a hydrophilic polymer, (ii) a bioadhesive substance, (iii) a first solvent and (iv) optionally, a drug substance, wherein

• the hydrophilic polymer is soluble in the first solvent and comprises one or more selected from polyvinylpyrrolidone (PVP), ethylcellulose, hydroxypropylcellulose, acrylates, polymers of acrylic/methacrylic esters, and mixtures thereof;
• the bioadhesive substance has a solubility in the first solvent of 0.5 g/100 ml or less at 25° C. and comprises one or more selected from dextrans, polyethylene oxides (PEOs), alginate, tragacanth, carrageenan, pectin, guar, xanthan, gellan, methylcellulose, hydroxypropylmethylcellulose (HPMC), polyvinylalcohol (PVA), polymers of acrylic acids (PAAs), chitosan, lectins, thiolated polymers, nonionic water-soluble polyethylene oxide resins (polyox WSR), and PAA polyethylene glycol copolymers (PAA-co-PEG), and mixtures thereof,
• wherein at least a portion of the bioadhesive substance is attached to the fibers as particles in an undissolved form, wherein the portion of the bioadhesive substance attached to the fibers in an undissolved form is not an integral part of the fibers.