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US 10,047,112 B2Granted
Fluorescent labeled inhibitors
AssigneeThe Curators of the University of Missouri
InventorsChristopher D. Spilling, Benjamin P. Martin, Stephane Canaan, Jean-Francois Cavalier
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Abstract
Provided herein are a series of fluorescently labeled phosphonate and phosphate compounds such as can be used for affinity probes to detect certain enzymes including lipases. Also provided are methods of making and using such compounds.
Claims20
A compound comprising a cyclic enolphosphonate or a cyclic enolphosphate, having the structure:
- wherein n is any of 1 to 20:
- wherein R is alkyl, benzyl, or aryl;
- wherein R′ is any of C1 to C20:
- wherein X is O or CH2;
- and wherein Y is a fluorescent label;
- or
- wherein n is any of 1 to 20;
- wherein R is alkyl, benzyl, or aryl;
- wherein R′ is any of C1 to C20;
- wherein X is O or CH2;
- and wherein Y is a fluorescent label.
8 more elements
Dependencies are inferred from the claim text.