Polymer coated biodegradable stent material and methods of use
AssigneeThe Florida International University Board of Trustees
InventorsNorman Munroe, Elnaz Mirtaheri
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Abstract
The invention pertains to methods of treating alloys, particularly, biodegradable alloys containing Mg, Zn or Fe. The alloys can be treated with at least one of the following procedures: mechanical polishing, anodization, and polymer coating. Advantageously, methods provided herein enhance the anti-thrombogenicity of the alloy surface. Such materials can be used for preparing biomedical devices, such as endovascular implants, vascular implants, drug-eluting stents, orthopedic prostheses, or implantable chips. Methods of treating a subject by implanting the biomedical devices into the subject are also provided.
Claims16
A method for treating a surface of an alloy, comprising treating the surface with all of the following:
- mechanical polishing, electrochemical treatment, and applying a polymer coating, wherein the alloy is Mg1Zn, Mg1Zn1Ca, Mg1Zn1Ca8Gd, Mg1Zn1Ca1HA, Mg1Zn1Ca3HA, Mg5Zn1Ca, Mg5Zn1Ca1HA, or Mg5Zn1Ca3HA, and wherein the electrochemical treatment comprises anodization.
A device comprising an alloy, wherein a surface of the device is treated according to all of the following:
- mechanical polishing, an electrochemical treatment, and applying a polymer coating, wherein the alloy Mg1Zn, Mg1Zn1Ca, Mg1Zn1Ca8Gd, Mg1Zn1Ca1HA, Mg1Zn1Ca3HA, Mg5Zn1Ca, Mg5Zn1Ca1HA, or Mg5Zn1Ca3HA, and wherein the electrochemical treatment comprises anodization.
A device comprising a biodegradable alloy, wherein a surface of the device is treated according to all of the following:
- mechanical polishing, electrochemical treatment, and applying a polymer coating;
- wherein:
- a) the biodegradable alloy is Mg1Zn, Mg1Zn1Ca, Mg1Zn1Ca8Gd, Mg1Zn1Ca1HA, Mg1Zn1Ca3HA, Mg5Zn1Ca, Mg5Zn1Ca1HA, or Mg5Zn1Ca3HA,
- b) the surface of the device has a roughness from 0.040 μm to 0.060 μm,
- c) the electrochemical treatment comprises anodization, and
- d) the polymer coating comprises poly(glycolic acid-co-caprolactone), poly(glycolic acid-co-trimethylene carbonate), poly(lactic-co-glycolic acid), or a combination thereof.
Dependencies are inferred from the claim text.