Glycotargeting therapeutics
AssigneeEcole Polytechnique Federale De Lausanne (Epfl)
InventorsJeffrey A. Hubbell, David Scott Wilson
Life of this patent
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Abstract
Several embodiments of the present disclosure relate to glycotargeting therapeutics that are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein.
Claims25
A composition comprising a compound of Formula 1:
- XY—Z]L Formula 1
- where:
- m is an integer from about 1 to 100;
- X comprises an antigen against which a patient develops an unwanted immune response;
- Y comprises
- where:
- the left bracket “(” indicates the bond between X and Y;
- the bottom bracket and “)” indicates the bond between Y and Z;
- n is an integer from about 1 to 100;
- R9 is —CH2— or —CH2—CH2—C(CH3)(CN)—;
- and
- W represents a polymer of the same W1 group, or W is a copolymer or a random copolymer of the same or different W1 and W2 groups, where:
- where:
- p is an integer from 2 to about 150;
- R9 is a direct bond, —C(O)—NH—CH2—CH2—, or —C(O)—NH—(CH2—CH2—O—)t—CH2—CH2—;
- t is an integer from 1 to 5;
- and
- R10 is an aliphatic group, an alcohol or an aliphatic alcohol;
- and
- Z comprises one or more liver-targeting moieties.
A composition for inducing tolerance to an antigen to which a subject develops an unwanted immune response, the composition comprising a compound of Formula 1:
- XY—Z]L Formula 1
- where:
- m is an integer from about 1 to 10;
- X comprises an antigen to which patients develop an unwanted immune response, wherein the antigen is a food antigen, a therapeutic agent, or a self-antigen;
- Y is:
- wherein:
- the left bracket “(” indicates a bond to X;
- the bottom bracket and “)” indicates the bond between Y and Z;
- n is an integer from about 1 to 100;
- R8 is —CH2—CH2—C(CH3)(CN)—;
- W represents a polymer of the same W1 group, or W is a copolymer or a random copolymer of the same or different W1 and W2 groups, where:
- where:
- p is an integer from 2 to about 150;
- where present R9 is a direct bond, —C(O)—NH—CH2—CH2—, or —C(O)—NH—(CH2—CH2—O—)t—CH2—CH2—;
- t is an integer from 1 to 5;
- and
- R10 is an aliphatic group, an alcohol, or an aliphatic alcohol;
- and
- Z comprises one or more of galactose, galactosamine, N-acetylgalactosamine, glucose, glucosamine, or N-acetyl glucosamine.
Dependencies are inferred from the claim text.