Inflammation inhibiting compounds
OwnerThomas Lugerinventor
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Abstract
The present invention relates to the use of compounds selected from the group consisting of Lys-(D)Pro-Thr, N-acyl Lys-(D)Pro-Thr, C-amide Lys-(D)Pro-Thr, and C-esters of Lys-(D)Pro-Thr; or a pharmaceutically acceptable salt of said compound for the treatment of inflammatory disorders. The invention also relates to the use of αMSH for inducing tolerance.
Claims8
A method for treatment of inflammation resulting from a disorder selected from the group consisting of enterocolitis, allergic reactions, food allergies, rheumatoid arthritis, multiple sclerosis, asthma, contact allergies, rhinitis, atopic dermatitis, transplant rejection, scleroderma, and vasculitis, comprising the step of administering to a patient in need of such treatment, a pharmaceutical composition comprising a therapeutically effective amount of a compound selected from the group consisting of Lys-(D)Pro-Thr [K(D)PT] (KPT), N-acyl Lys-(D)Pro-Thr, C-amide Lys-(D)Pro-Thr, and C-esters of Lys-(D)Pro-Thr;
- or a pharmaceutically acceptable salt of said compound, wherein said therapeutically effective amount is in the range from 20 μg/kg of body weight to 10 mg/kg of body weight.
A method for the treatment of inflammation of the skin resulting from a disorder selected from the group consisting of allergic reactions, rheumatoid arthritis, contact allergies, rhinitis, atopic dermatitis and scleroderma and comprising the step of administering to a patient in need of such treatment, a medicament formulated for topical application, said medicament containing a pharmaceutical composition comprising a therapeutically effective amount of a compound selected from the group consisting of Lys-(D)Pro-Thr [K(D)PT](KPT), N-acyl Lys-(D)Pro-Thr, C-amide, Lys-(D)Pro-Thr, and C-esters of Lys-(D) Pro-Thr;
- or a pharmaceutically acceptable salt of said compound, wherein said compound is present in said preparation in a concentration of from 1 μM to 1 mM.
Dependencies are inferred from the claim text.