Bicyclic compound, production and use thereof

A method for treating cancer which comprises administering an effective amount of a compound of Formula I,

• or a salt or hydrate thereof,
• wherein,
• Z1a is a 5- or 6-membered aromatic ring group;
• Z2′ is a group of —Z2a—W2—Z2b—;
• wherein each of Z2a and Z2b is O, S(O)m (wherein m is 0, 1, or 2), an optionally substituted imino group, or a bond;
• W2 is an optionally substituted alkylene chain;
• n is 1;
• Y is NR4, wherein R4 is hydrogen, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted acyl group;
• R2′ is (1) an optionally substituted amino group and whose nitrogen atom is optionally converted to quaternary ammonium or oxide;
• (2) a nitrogen-containing heterocyclic group which is optionally substituted and may contain a sulfur atom or an oxygen atom as a ring constituent atom, and whose nitrogen atom is optionally converted to quaternary ammonium or oxide;
• (3) an optionally substituted amidino group;
• or (4) an optionally substituted guanidino group;
• R1 is an optionally substituted cyclic 5- to 6-membered ring;
• and
• wherein the cancer is selected from the group consisting of gastric cancer, cachexia, bladder cancer, breast cancer, cervical cancer, ovarian cancer, chronic lymphoblastic leukemia, chronic myeloid leukemia, colon cancer, rectal cancer, colic cancer, multiple myeloma, malignant myeloma, prostatic cancer, lung cancer, Hodgkin disease, melanoma, lymphoma, non-Hodgkin's lymphoma, and non-small cell lung cancer.