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US 10,041,943 B2Granted
Methods of using chimeric receptors to identify autoimmune disease
AssigneeDiagnostic Hybrids, Inc.
InventorJames L Brown
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Abstract
The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays.
Claims12
A method, comprising:
- i) preparing a recombinant plasmid vector, wherein the recombinant plasmid vector comprises:
- a) a chimeric thyrotropin stimulating hormone (TSH) receptor gene, and
- b) a reporter gene;
- wherein, the chimeric TSH receptor gene encodes a polypeptide having an N-terminal portion encoded by nucleotides 45-2234 of SEQ ID NO:
- 3.
2 more elements
Dependencies are inferred from the claim text.