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US 10,041,077 B2Granted
DNA vectors, transposons and transposases for eukaryotic genome modification
AssigneeDna2.0, Inc.
InventorsJeremy Minshull, Maggie Lee
Life of this patent
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Abstract
The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel transposons and transposases that further improve expression. Further disclosed are vectors that can be used in a gene transfer system for stably introducing nucleic acids into the DNA of a cell. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.
Claims20
A polynucleotide comprising a segment having a sequence at least 99% identical to SEQ ID NO:
- 866, wherein the segment comprises SEQ ID NO:
- 869 and either SEQ ID NO:
- 867 or 868, the segment effective to enhance expression of a gene incorporating the segment between a coding sequence and 3′ polyA sequence.
Dependencies are inferred from the claim text.