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US 10,040,854 B2Granted
Antibodies against CD106 (VCAM-1)
AssigneeOxford University Innovation Limited
InventorsDaniel Clive Anthony, Sandra Jane Campbell, Francis Joseph Carr, Robin Patrick Choudhury, Benjamin Guy Davis, Timothy David Jones, Nicola Ruth Sibson
Life of this patent
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Abstract
The invention provides an antibody or fragment thereof that specifically binds to human endothelial vascular cell adhesion molecule-1 (VCAM-1), wherein the antibody or fragment thereof binds to the extracellular domain of VCAM-1, and wherein the antibody or fragment thereof binds to VCAM-1 when expressed on endothelial cells, wherein the antibody or fragment thereof is a human or humanized antibody, or fragment thereof.
Claims14
A humanized antibody, or fragment thereof, comprising:
- a heavy chain that comprises from the heavy chain variable region of SEQ ID NO:10, at least a CDR1 comprising TSGLG from SEQ ID NO:11, a CDR2 comprising VYWDDDK from SEQ ID NO:12, and a CDR3 comprising RAFYGNNGAYAMDY from SEQ ID NO:13, and
- a light chain that comprises from the light chain variable region of SEQ ID NO:4 at least a CDR1 comprising QSISDY from SEQ ID NO:5, a CDR2 comprising YAS from SEQ ID NO:6, and a CDR3 comprising SEQ ID NO:7,
- wherein the antibody or fragment thereof specifically binds human endothelial vascular cell adhesion molecule 1 (VCAM-1).
Dependencies are inferred from the claim text.