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US 10,040,849 B2Granted
Caninized anti-nerve growth factor antibodies
AssigneeNexvet Australia Pty Ltd
InventorDavid Gearing
Life of this patent
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Abstract
A method of preparing an antibody suitable for use in a canine is provided. Also provided are caninized antibodies which specifically bind to canine neuronal growth factor (NGF) and neutralize the ability of canine NGF to bind to the p75 or TrkA canine NGF receptor. The invention extends to nucleic acids encoding same and to methods of treating pain and arthritis in a canine using said antibodies and/or nucleic acids.
Claims1
A caninized antibody or caninized antigen binding fragment thereof, wherein the light chain variable region comprises the amino acid sequence of SEQ ID NO:
- 1 and the heavy chain variable region comprises the amino acid sequence of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.