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US 10,040,829 B2Granted
Methods for producing peptides including HERV-W envelope motifs and for producing antibodies specific for the peptides
AssigneeBiomerieux
InventorsFrancois Mallet, Guy Oriol, Valerie Cheynet
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Abstract
A peptide domain necessary for an interaction between an envelope of a virus belonging to an HERV-W interference group and an hASCT receptor comprises (i) an N-terminus motif having an amino acid sequence selected from the group consisting of: SEQ ID No. 1 to SEQ ID No. 29, (ii) a C-terminus motif having an amino acid sequence selected from the group consisting of: SEQ ID No. 30 to SEQ ID No. 40, and (iii) at least one motif between the N-terminus and the C-terminus, and having an amino acid sequence selected from the group consisting of: SEQ ID No. 41, SEQ ID No. 42 and SEQ ID No. 73.
Claims17
A method comprising:
- chemically synthesizing a peptide;
- or
- performing genetic engineering to produce the peptide,
- wherein the peptide is no longer than the receptor binding domain of the HERV-W envelope protein and comprises:
- an N-terminus motif including an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1 to SEQ ID NO:
- 29;
- a C-terminus motif including an amino acid sequence selected from the group consisting of SEQ ID NO:
- 30 to SEQ ID NO:
- 40;
- and
- at least one motif between the N-terminus and the C-terminus including an amino acid sequence selected from the group consisting of SEQ ID NO:
- 41, SEQ ID NO:
- 42, and SEQ ID NO:
- 73.
12 more elements
Dependencies are inferred from the claim text.