Compositions targeting bradykinin receptor B1 for medical imaging of cancer and other disorders

A bradykinin B1 receptor (B1R) targeting compound that selectively binds to B1R, comprising:

• a peptidic compound having general Formula (I) or a non-peptidic compound having general Formula (III):
• B-L-Xaa1-Xaa2-Arg-Pro-Xaa3-Gly-Xaa4-Ser-Xaa5-Xaa6 (I)
• wherein:
• B is a radio-labelled moiety, radiometal chelating agent, N-succinimidyl-4-[18F]fluorobenzoate (SFB), D-Pra,
• L is a linker;
• Xaa1 is Lys or Sar;
• Xaa2 is Lys or D-Arg;
• Xaa3 is Pro or Hyp;
• Xaa4 is Phe, Cha, Thi, (α-Me)Phe, Igl or Cpg;
• Xaa5 is Pro, D-Tic, D-Hyp, D-βNal or D-Igl, and
• Xaa6 is Leu, Ile, D-Phe, Cpg or Oic [SEQ ID NO:
• 31], wherein Xaa6 is not peptide-bonded to Arg, and
• wherein when B is a radiometal chelating agent, it is optionally chelated to a radiolabel;
• wherein:
• R1, R4 and R5 are each independently H or Me;
• R2 is H or halo;
• R3 is H, Me, halo or OMe;
• ˜NR6R7 is:
• Y is (CH2)mNHR or
• R is (CH2)p;
• R8 is Me or Et;
• X is O or CH2;
• NR9R10 is
• n, m, p, q and t are each independently 0, 1 or 2, and
• u and v are each independently 1 or 2, and
• wherein F is optionally 18F.