Adamantane or pinene derivatives for use in the treatment of chlamydiales infections
AssigneeCommissariat A L'energie Atomique Et Aux Energies Alternatives
InventorsDaniel Gillet, Julien Barbier, Jean-Christophe Cintrat, Valérie Pons, Thomas Rudel, Jo-Ana Herweg, Annette Fischer
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Abstract
The present invention relates to a method for treating a Chlamydiales infection comprising the administration of a therapeutically effective amount of a compound of formula (I) to a subject in need thereof: W-L1-NH-L2-Ar (I) Wherein W, L1, L2 and Ar are as defined in claim 1.
Claims15
A method for treating a Chlamydiales infection comprising the administration of a therapeutically effective amount of a compound of formula (I) to a subject in need thereof
- W-L1-NH-L2-Ar (I)
- wherein:
- W is
- L1 is independently selected from a single bond, or (CH2)pC(═O)—,
- L2 is independently selected from (CH2)q—, [—C(═O)—NH]r—N═CH—, or —(C6H4)—SO2—NH—,
- Ar is a C6-C10 aryl, said aryl group being substituted by one to three R groups, R being independently selected from Cl, Br, I, C1-C6 alkyl, C1-C6 alkoxy, and NO2,
- p is 0, 1 or 2,
- q is 1 or 2, and
- r is 0 or 1,
- and or the stereoisomeric forms, or mixtures of stereoisomeric forms or pharmaceutically acceptable salts forms thereof.
A pharmaceutical composition comprising a compound of formula I:
- W-L1-NH-L2-Ar (I)
- wherein:
- W is
- L1 is independently selected from a single bond, or —(CH2)pC(═O)—,
- L2 is independently selected from —(CH2)q—, [—C(═O)—NH]r—N═CH—, or —(C6H4)—SO2—NH—,
- Ar is a C6-C10 aryl, said aryl group being substituted by one to three R groups, R being independently selected from the group consisting of Cl, Br, I, C1-C6 alkyl, C1-C6 alkoxy, and NO2,
- p is 0, 1 or 2,
- q is 1 or 2, and
- r is 0 or 1,
- or the stereoisomeric forms, or mixtures of stereoisomeric forms or pharmaceutically acceptable salts forms thereof,
- in admixture with one or more pharmaceutically acceptable excipients.
Dependencies are inferred from the claim text.