Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors
AssigneeKudos Pharmaceuticals Limited
InventorsHeather Mary Ellen Duggan, Frederic Georges Marie Leroux, Karine Fabienne Malagu, Niall Morrison Barr Martin, Keith Menear, Graeme Cameron Murray Smith
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Abstract
There is provided a compound of formula I: or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.
Claims4
A pharmaceutical composition for treating cancer ameliorated by inhibition of mTOR in a warm blooded animal having said cancer comprising a therapeutically-effective amount of a compound of formula lap:
- or a pharmaceutically acceptable salt thereof, in association with a pharmaceutically-acceptable diluent or carrier, in combination with a taxoid.
A method of treating cancer ameliorated by inhibition of mTOR in a warm blooded animal having said cancer comprising administering to the animal an effective amount of a compound of formula lap:
- or a pharmaceutically acceptable salt thereof, in association with a pharmaceutically-acceptable diluent or carrier, in combination with a taxane.
Dependencies are inferred from the claim text.