Monitoring of the freezing state of a biopharmaceutical fluid found in a container
AssigneeSartorius Stedim North America Inc.
InventorJonathan Cutting
Life of this patent
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Abstract
A device for monitoring the freezing state of a biopharmaceutical fluid in a container intended to receive a biopharmaceutical fluid that must pass between the liquid state and the frozen state, includes a peripheral envelope (25) made of plastic, to be connected to a heat treatment receptacle (5), a sensor (19) suitable for detecting a control parameter which is a macroscopic parameter of the container, and an analysis system (62) suitable for determining a freezing state of the biopharmaceutical fluid on the basis of the macroscopic parameter of the container.
Claims20
Monitoring device for monitoring the freezing state of a biopharmaceutical fluid in a container intended to receive a biopharmaceutical fluid that is to transition between the liquid state and the frozen state, wherein the device comprises a peripheral envelope made of plastic, intended and suitable for association with a thermal treatment receptacle,
- wherein the device further comprises a sensor suitable for non-intrusively detecting a control parameter which is a macroscopic parameter of the container, and an analysis system suitable for determining a freezing state of the biopharmaceutical fluid on the basis of the macroscopic parameter of the container, the macroscopic parameter being derived directly or indirectly from an average density of a non-gaseous portion of contents of the container.
Method for monitoring the freezing state of a biopharmaceutical fluid in a container intended to receive a biopharmaceutical fluid that is to transition between the liquid state and the frozen state, comprising a peripheral envelope of plastic, intended and suitable for association with a thermal treatment receptacle, wherein a sensor non-intrusively detects a control parameter which is a macroscopic parameter of the container, and an analysis system determines a freezing state of the biopharmaceutical fluid on the basis of the macroscopic parameter of the container, the macroscopic parameter being derived directly or indirectly from an average density of a non-gaseous portion of contents of the container.
Dependencies are inferred from the claim text.