Biodegradable matrix comprising stem cells that express soluble TRAIL
AssigneeThe General Hospital Corporation
InventorKhalid Shah
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Abstract
Described herein are novel compositions comprising multimodal TRAIL agents and cells engineered to express such multimodal TRAIL agents, including cells encapsulated in a scaffold or matrix, for use in the treatment of disorders such as cancer.
Claims16
A biodegradable matrix or scaffold that permits stem cell migration from said matrix or scaffold, the matrix or scaffold comprising a stem cell comprising a nucleic acid sequence encoding a polypeptide comprising a soluble TRAIL fusion protein comprising a reporter module, a linker module, and a therapeutic TRAIL module comprising an extracellular domain of human TRAIL of SEQ ID NO:
- 1.
A biodegradable matrix or scaffold that permits stem cell migration from said matrix or scaffold, the matrix or scaffold comprising a stem cell comprising a heterologous nucleic acid sequence encoding a soluble TRAIL polypeptide comprising an extracellular domain of human TRAIL of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.