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US 10,030,052 B2Granted
Parvovirus Vp1 unique region polypeptides and compositions thereof
AssigneeGlaxosmithkline Biologicals SA
InventorsEthan Settembre, Sumana Chandramouli
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Abstract
The present invention is directed to mutant parvovirus VP1 unique region polypeptides, compositions comprising such polypeptides, methods of making such compositions, as well as methods for identifying the likely presence of parvovirus-neutralizing antibodies, and methods for assessing the functional immunogenicity of parvovirus vaccines and measuring a correlate of efficacy to assess a treatment for parvovirus infection.
Claims6
A polypeptide comprising a parvovirus VP1 unique region selected from SEQ ID NO:
- 1, SEQ ID NO:
- 4, SEQ ID NO:5 and SEQ ID NO:6, wherein the sequence of amino acids at positions 167-171 of said parvovirus unique region has at least two amino acid mutations, where each of said mutations is an amino acid substitution or an amino acid deletion, and wherein the parvovirus VP1 unique region does not cross-react with antibodies that bind parvovirus VP2.
Dependencies are inferred from the claim text.