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US 10,029,968 B2Granted
Process for producing alcohol analogue
AssigneeTakasago International Corporation
InventorsMotomu Kanai, Shigeki Matsunaga
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Abstract
Provided is a process for producing an optically active hydroxyaldehyde or aminohydroxyaldehyde. The process for producing an optically active hydroxyaldehyde or aminohydroxyaldehyde is characterized by reacting an aldehyde or an imine with a boric acid enol ester in the presence of a copper compound and an optically active bidentate phosphine compound.
Claims8
A method for producing a compound represented by the following general formula (3):
- (wherein, R1 represents an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group. R2 represents a hydrogen atom or a C1-6 alkyl group. Y represents a hydroxy group or NHX (X represents an optionally substituted thiophosphinoyl group). n represents 0 or 1.
- * represents an asymmetric carbon atom.),
- characterized in that a borate enol ester represented by the following general formula (2):
- (wherein, R2 represents a hydrogen atom or a C1-6 alkyl group. R3 and R4 each represents a C1-4 alkyl group, or R3 and R4 optionally together form a methylene chain which is optionally substituted with alkyl group(s).) is reacted with a compound represented by the following general formula (1):
- R1CH =Z (1)
- (wherein, R1 represents an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group. Z represents an oxygen atom or NX (X represents an optionally substituted thiophosphinoyl group.)) in the presence of a copper compound and an optically active bidentate phosphine compound.
3 more elements
Dependencies are inferred from the claim text.