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US 10,023,965 B2Granted
Electrolytic buffer generator
AssigneesBoard of Regents, The University of Texas System, Dionex Corporation
InventorsPurnendu K. Dasgupta, Yongjing Chen, Kannan Srinivasan
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Abstract
Buffer generators are described based on electrodialytic devices. The methods of using these devices can generate buffers for diverse applications, including separations, e.g., HPLC and ion chromatography. Also provided are chromatographic devices including the buffer generators, generally located upstream from a chromatography column, sample injector valve or both.
Claims5
An electrodialytic method for generating a modified buffer solution, said method comprising:
- (a) flowing a first buffer solution including cations and anions to a modified-buffer generation flow channel;
- (b) flowing an aqueous solution including cations and anions to a source channel separated from said modified-buffer generation flow channel by a first ion exchange barrier, and capable of exchanging cations or anions, but not both, and blocking bulk liquid flow, in which a first electrode is disposed in said source channel;
- (c) flowing a deionized water stream to a receiving channel separated from said modified-buffer generation flow channel by a second ion exchange barrier, and capable of exchanging cations or anions, but not both, and blocking bulk liquid flow, in which a second electrode is disposed in said receiving channel, wherein said first ion exchange barrier and said second ion exchange barrier are anion exchange barriers, or said first ion exchange barrier and said second ion exchange barrier are cation exchange barriers;
- and
- (d) passing a current between said first and second electrodes across said modified-buffer generation flow channel to cause cations or anions, but not both, of said source channel to be transported across said first ion exchange barrier to said modified-buffer generation flow channel, and to cause cations or anions, but not both, of said modified-buffer generation flow channel to be transported across said second ion exchange barrier to said receiving channel to generate a modified buffer solution which exits from said modified-buffer generation flow channel;
- wherein said modified-buffer generation flow channel is fluidically coupled to a chromatography column upstream of said chromatography column.
3 more elements
Dependencies are inferred from the claim text.