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US 10,022,475 B2Granted
Body augmentation device
AssigneeBao Tran
InventorsPhi Nguyen, Loc Phan, Bao Tran, Thuan Nguyen, Duy Bui
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Abstract
Systems and methods are disclosed for body augmentation by mixing hyaluronic acid (HA) with polyvinyl alcohol (PVA) to form an HA-PVA hydrogel; and exposing the HA-PVA hydrogel to one or more freeze-thaw cycles or to an amount of radiation effective to crosslink the HA to the PVA to crosslink the HA to the PVA.
Claims20
A method for body augmentation, comprising:
- storing a non-toxic biocompatible material;
- storing a biocompatible polymer having a multi-phase mixture with a predetermined controlled release of selected pharmaceutical substance to modulate soft tissue response to the polymer;
- mixing the biocompatible material and polymer to cross-link the mixture by exposing HA-PVA (hyaluronic acid-polyvinyl alcohol) hydrogel to an amount of ionizing radiation providing a radiation dose effective to crosslink the HA to the PVA and providing a mask;
- and
- augmenting soft tissue with the cross-linked mixture.
2 more elements
A method of making a cross-linked hydrogel comprising:
- storing a biocompatible material and storing a biocompatible polymer having a multi-phase mixture with a predetermined controlled release of selected pharmaceutical substance to modulate soft tissue response to the polymer;
- mixing hyaluronic acid (HA) with polyvinyl alcohol (PVA) to form an HA-PVA (hyaluronic acid-polyvinyl alcohol) hydrogel;
- and
- exposing the HA-PVA hydrogel to an amount of energy effective to crosslink the HA and the PVA and to sterilize the container content.
1 more element
A method, comprising
- storing a non-toxic biocompatible material and a biocompatible polymer having a multi-phase mixture with a predetermined controlled release of selected pharmaceutical substance to modulate soft tissue response to the polymer;
- mixing the biocompatible material and polymer to cross-link the mixture;
- forming a biocompatible cross-linked polymer having an interpenetrating polymer network (IPN) including:
- cross-linking a heteropolysaccharide to form a single cross-linked material;
- and
- performing one or more additional cross-linkings on the single cross-linked material to form a multiple cross-linked material,
- wherein the multiple cross-linked material has one or more IPN regions resisting biodegradation in a human body than the single cross-linked material and one or more single cross-linked extensions radiating out from the IPN, wherein the combination of the IPN and the extension provide one or more of:
- biodegradation resistance, soft touch feeling, ease of insertion into the human body and augmenting soft tissue with the cross-linked mixture.
5 more elements
Dependencies are inferred from the claim text.