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US 10,022,391 B2Granted
Maintenance of platelet inhibition during antiplatelet therapy
AssigneeChiesi Farmaceutici S.p.A.
InventorsLisa Ruderman Chen, Simona Skerjanec, Dawn Bell, Jayne Prats, Meredith Todd
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Abstract
A method for reducing or maintaining platelet inhibition in a patient by administering cangrelor prior to an invasive procedure is described. The method of this invention can be used for patients in need of antiplatelet therapy or at risk of thrombosis. The method can further be used in patients who were previously treated with long-acting platelet inhibitors without increasing the risk of excessive bleeding.
Claims10
A method of maintaining P2Y 12 inhibition in a patient being treated with an oral P2Y 12 inhibitor who is in need of surgery, the method comprising:
- (a) discontinuing the treatment with the oral P2Y12 inhibitor;
- (b) administering intravenously a 4 μg/kg/min continuous infusion of cangrelor;
- and
- (c) continuing the administration of the continuous infusion for the longer of (i) at least two hours, or (ii) the duration of surgery.
1 more element
Dependencies are inferred from the claim text.