Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using ELISA assays
AssigneeBoard of Regents, The University of Texas System
InventorsMaher Albitar, Michael J. Keating, Taghi Manshouri
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Abstract
The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.
Claims7
A method for determining a dosage of a therapeutic anti-CD20 antibody for treating B cell hyperproliferative disease, the method comprising testing a sample from a human to measure the level of soluble CD20, and determining the dosage of the therapeutic anti-CD20 antibody according to the level of soluble CD20.
Dependencies are inferred from the claim text.