Hydrate of 2-isopropoxy-5-methyl-4-(piperidin-4-yl) aniline dihydrochloride, preparation method and use of the same
Assignee2Y-Chem, Ltd.
InventorsJinfeng Song, Xungui He, Wensheng Tang, Yuan Wang
Life of this patent
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Abstract
The present invention relates to 2-isopropoxy-5-methyl-4-(piperidin-4-yl) aniline dihydrochloride monohydrate and a preparation method of the same. The 2-isopropoxy-5-methyl-4-(piperidin-4-yl) aniline dihydrochloride monohydrate has a very good crystal form and is well suitable for recrystallization purification; further, the effect of impurity removal effect is very good, and any single impurity can be controlled less than 0.1%.
Claims3
A crystal form A of 2-isopropoxy-5-methyl-4-(piperidin-4-yl)aniline dihydrochloride monohydrate, wherein the X-ray powder diffraction pattern thereof exhibits characteristic peaks at the following 2θ±0.2 degrees:
- 10.4°, 13.4°, 15.9°, 17.3°, 19.3°, 20.3°, 20.9°, 21.4°, 21.9°, 23.6°, 24.5°, 25.3°, 25.8°, 26.2°, 27.0°, 27.8°, 28.2°, 29.5°, 30.9°, 31.5°, 32.2°, 33.6°, 34.2°, 35.0°.
Dependencies are inferred from the claim text.