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US 10,017,463 B2Granted
Inhibitors of deubiquitinating proteases
AssigneeBrandeis University
InventorsLizbeth K. Hedstrom, Marcus J. Long, Ann Parrinello Lawson
Life of this patent
Estimating the term…
Abstract
Disclosed are small molecule inhibitors of deubiquitinating enzymes (DUBs), and methods of using them. Certain compounds are selective for particular ubiquitin-specific proteases (USPs).
Claims7
A compound selected from the group consisting of:
A method of treating a cancer, comprising the step of:
- administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of:
- wherein the cancer is leukemia, myeloma, lung cancer, colon cancer, central nervous system (CNS) cancer, melanoma, ovarian cancer, renal cancer, prostate cancer, or breast cancer.
Dependencies are inferred from the claim text.