Compounds for promoting liposomal and cellular adhesion and compositions and methods of use thereof
AssigneeOrganolinx Corp.
InventorMuhammad Naveed Yousaf
Life of this patent
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Abstract
The present application describes amphiphatic compounds like compound IIa below, compositions and methods for incorporating chemoselective and bio-orthogonal complementary functional groups into liposomes. Such compounds are incorporated in greater numbers in liposome and fused cell surfaces, leading to greater adhesion and conjugation efficiency. The present application also describes various uses of these modified liposomes including for tethering the chemoselective and bioorthogonal complementary functional groups from cell surfaces by liposome delivery toward the goal of rewiring the cell surface.
Claims22
A compound of the Formula IV:
- R—X (IV)
- wherein R is selected from:
- H3C—(CH2)n—[—O—(CH2)m—]p—O—(CH2)q—;
- H3C—(CH2)n-Q-[—O—(CH2)m]p—O—(CH2)q—;
- and
- H3C—(CH2)n—[—O—(CH2)m]p—O—(CH2)q-Q-;
- n is 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28 or 29;
- m is 1, 2, 3, or 4;
- p is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10;
- q is 0, 1, 2, 3, 4, 5 or 6;
- Q comprises at least one of a fluorescent moiety, hydroquinone, ferrocene, a photocleavable moiety, a radioactive moiety, a chelating moiety and a spin label;
- and
- X is selected from C(O)H, C(O)R1 and O—NH2 and R1 is C1-2alkyl,
- provided that when R is H3C—(CH2)n—[—O—(CH2)m—]p—O—(CH2)q— and X is C(O)H or C(O)R1, m is 1, 3 or 4.
A compound of the Formula V:
- wherein R2 and R3 are each, independently selected from
- H3C—(CH2)n—[—O—(CH2)m—]p—O—(CH2)q—;
- H3C—(CH2)n-Q-[—O—(CH2)m]p—O—(CH2)q—;
- H3C—(CH2)n—[—O—(CH2)m]p—O—(CH2)q-Q-;
- and
- H3C—(CH2)n—O—(CH2)q—;
- n is 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28 or 29;
- m is 1, 2, 3, or 4;
- p is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10;
- q is 0, 1, 2, 3 or 4;
- Q comprises at least one of a fluorescent moiety, hydroquinone, ferrocene, a photocleavable moiety, a radioactive moiety, a chelating moiety and a spin label;
- r and r′ are each independently, 1, 2 or 3;
- and
- X and X′ are each, independently, one of a complementary functional group pair.
Dependencies are inferred from the claim text.