US 10,016,444 B2 · Molecules for bone tissue regeneration

Abstract

The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts thereof: (I) wherein Ri is selected from an SCN— group or is an RCONH— group; in particular, where Ri=RCONH, R is selected from an aromatic benzene ring substituted with an SCN— group in the ortho, meta or para position, according to the following formula: SCN— or R is a C1-C4 alkyl chain, substituted with an SCN— group; n can be equal to 0 or else 1. The invention also relates to the use of such compounds for the treatment of osteoporosis and in general of bone pathologies characterized by a progressive loss of bone mass, for example rheumatoid arthritis, hyperparathyroidism or bone tumor metastases.

Claims7

Dependent claims

A compound of formula (I) or pharmaceutically acceptable salt thereof:

wherein R1 is an RCONH— group, wherein R is an aromatic benzene ring substituted with an SCN— group in the ortho, meta or para position, according, to the following formula:
and n can be equal to 0 or 1.

Dependencies are inferred from the claim text.

Facts

Application

15/524,257Filed 5 Nov 2015

Priority

IT MI2014A19197 Nov 2014

Published

US 2017/0319605 A19 Nov 2017

Granted

10 Jul 2018

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61K 31/663
Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon: compounds having two or more phosphorus acid groups or esters…
C07C 331/24
Of an unsaturated carbon skeleton: the carbon skeleton containing six-membered aromatic rings
C07C 331/28
Isothiocyanates: having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings
C07F 9/38
With one or more P—C bonds: phosphonic acids [RP2]; Thiophosphonic acids ; [RP2]

Molecules for bone tissue regeneration

Life of this patent

Molecules for bone tissue regeneration

Life of this patent

Abstract

Claims7