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US 10,011,658 B2Granted
Constructs targeting AFP peptide/MHC complexes and uses thereof
AssigneeEureka Therapeutics, Inc.
InventorsCheng Liu, Hong Liu, Yiyang Xu, Jingyi Xiang, Li Long
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Abstract
The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising an AFP peptide and an MHC class I protein. Also provided are methods of making and using these constructs.
Claims24
An isolated anti-AMC construct comprising an antibody moiety that specifically binds to a complex comprising an alpha-fetoprotein (AFP) peptide and a major histocompatibility (MHC) class I protein (AFP/MHC class I complex, or AMC), wherein the AFP peptide comprises the amino acid sequence of SEQ ID NO:
- 4, wherein the MHC class I protein is HLA-A02, and wherein the antibody moiety comprises:
- a heavy chain variable domain comprising a heavy chain complementarity determining region (HC-CDR)1 comprising the amino acid sequence of SEQ ID NO:
- 63, an HC-CDR2 comprising the amino acid sequence of SEQ ID NO:
- 73, and an HC-CDR3 comprising the amino acid sequence of SEQ ID NO:
- 83;
- and
- a light chain variable domain comprising a light chain complementarity determining region (LC-CDR)1 comprising the amino acid sequence of SEQ ID NO:
- 96, an LC-CDR2 comprising the amino acid sequence of SEQ ID NO:
- 106, and an LC-CDR3 comprising the amino acid sequence of SEQ ID NO:
- 116.
7 more elements
Dependencies are inferred from the claim text.