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US 10,011,603 B2Granted
Process for preparing a carbapenem antibiotic
AssigneeJohnson Matthey Public Limited Company
InventorsJames Cookson, Robert John McNair, Deepak Vasant Satoskar
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Abstract
A process for the preparation of a carbapenem, includes the step of treating a solution of a protected carbapenem with hydrogen gas in the presence of a heterogeneous catalyst to form the carbapenem, wherein the heterogeneous catalyst includes at least two platinum group metals.
Claims15
A process for preparing a carbapenem that is meropenem, imipenem, ertapenem, thienamycin, panipenem, or doripenem, said process comprising the step of treating a solution of a protected carbapenem with hydrogen gas in the presence of a heterogeneous catalyst to form the carbapenem,
- wherein the protected carbapenem is protected meropenem, protected imipenem, protected ertapenem, protected thienamycin, protected panipenem, or protected doripenem, and the protected carbapenem comprises one or more protecting groups that are an unsubstituted benzyl, substituted benzyl, unsubstituted-carboxybenzyl, substituted-carboxybenzyl, or a combination thereof, and
- wherein the heterogeneous catalyst is a mixed metal catalyst that (a) is an alloy of the two or more platinum group metals;
- or (b) comprises at least two platinum group metals deposited on a single solid support.
Dependencies are inferred from the claim text.