Amino acid conjugates of quetiapine, process for making and using the same
AssigneeKemPharm, Inc.
InventorsTravis Mickle, Sven Guenther, Sanjib Bera
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Abstract
The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating amino acids. The present technology also provides methods of treating patients, pharmaceutical compositions and methods of synthesizing conjugates of the present technology.
Claims21
A composition comprising 2-(2-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethanol (quetiapine) conjugated to phenylalanine via an ester bond, a salt of the conjugate, or their combination.
A composition comprising a pharmaceutically acceptable excipient and quetiapine, conjugated to phenylalanine via an ester bond wherein the conjugate is represented by any one of the following structures:
A compound represented by one of the following structures:
Dependencies are inferred from the claim text.