# US 10,010,475 B2 · Systems and methods for treating amblyopia by visual stimulation of the brain > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,010,475 B2 - Document ID: US10010475B2 - Status: Granted - Kind: B2 - Application number: 15/181,998 - Filed: 2016-06-14 - Published: 2016-10-20 - Granted: 2018-07-03 - Earliest claimed: 2012-09-14 - Assignees: Visior Technologies, LTD - Applicants: Visior Technologies, LTD - Inventors: Ilan Vadai; Yuval Avni - Web page: https://patentgrep.com/patent/US10010475B2 ## CPC - A61H 5/00: Exercisers for the eyes - A61B 3/032: Devices for presenting test symbols or characters, e.g. test chart projectors (A61B3/036 takes precedence) - A61B 3/08: for testing binocular or stereoscopic vision, e.g. strabismus - A61B 3/085: {for testing strabismus} - A61H 5/005: {Exercisers for training the stereoscopic view} - G02B 27/017: {Head mounted} - A61H 2201/1604: Head - A61H 2201/165: Wearable interfaces - A61H 2201/5007: computer controlled - A61H 2201/5015: using specific interfaces or standards, e.g. USB, serial, parallel - A61H 2201/5097: wireless - A61H: PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY (electrotherapy, magnetotherapy, radiation therapy or ultrasound therapy A61N) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G02B: OPTICAL ELEMENTS, SYSTEMS OR APPARATUS ## Abstract A system for treating amblyopia through the visual stimulation of the brain through a predetermined regime is provided. The system for treating amblyopia comprises a headmountable visual content display device, a controller unit, a visual content source, a data storage device, a graphic processing unit and an audio source. A protocol useful for treating amblyopia by visual stimulation of the brain is also provided. A predetermined regime useful for treating amblyopia by stimulation of the brain is additionally provided. ## Claims ### Claim 1 A medical device system to increase cerebral blood flow by using an unconventional pre-programmed visual stimulator, comprising: a display device having a display area to display a streaming video content; a data storage device for storing a pre-programmed stimulation regime that is identical for different patients; a controller unit connected to the display device and the data storage device, wherein the controller unit is configured to: alter a level of a baseline intensity of an image parameter value at a frequency in a range of 0.5-60 Hz for the streaming video content in a continually repeating cycle, the cycle having a crest and a trough as compared to a baseline intensity; activate a recovery period of less than or equal to 1 time unit to permit blood vessels to rest and recover; wherein the recovery period temporarily stops the continually repeating cycle; and operate in real time to affect presentation of the streaming video content, wherein the image parameter value is selected from a group consisting of a brightness, a contrast, a saturation, a sharpness, a resolution, and any combination thereof. ### Claim 2 (depends on 1) The system of claim 1 configured to treat Amblyopia by applying a dichoptic presentation to each eye of the user. ### Claim 3 (depends on 1) The system of claim 1, wherein said display device is configured to substantially isolate user's eyes from external visual disturbances. ### Claim 4 (depends on 1) The system of claim 1, wherein said display device is operatively connected to an audio device configured to provide audio stimulation according to the pre-programmed stimulation regime. ### Claim 5 (depends on 1) The system of claim 1, wherein the controller unit comprises a graphic processing unit configured to alter the image parameter value according to the pre-programmed stimulation regime. ### Claim 6 (depends on 1) The system of claim 1, wherein the controller unit is additionally configured to insert an overlay object on the display area, and to trigger audio data configured to be coherently connected to said overlay object according to the pre-programmed stimulation regime. ### Claim 7 (depends on 1) The system of claim 1, wherein the controller unit is additionally configured to introduce a flicker event on the display area. ### Claim 8 (depends on 1) The system of claim 1, wherein the streaming visual content is streamed from a source selected from a group consisting of a video game console, a cable modem, a television, a computer, a digital camera, a camcorder, a DVD, a mobile phone, a portable media player, an offline video content storage device, a network online streaming video content and any combination thereof. ### Claim 9 A method of using a medical device system to increase cerebral blood flow by using an unconventional pre-programmed visual stimulator, comprising: obtaining a display device having a display area to display a streaming video content; a data storage device for storing a pre-programmed stimulation regime that is identical for different patients; and a controller unit connected to the display device and the data storage device; utilizing the pre-programmed stimulation regime that manipulates the controller unit to provide: altering a level of a visibly noticeable intensity of an image parameter value at a frequency in a range of 0.5-60 Hz for the streaming video content in a continually repeating cycle, the cycle having a crest and a trough as compared to a baseline intensity; activating a recovery period of less than or equal to 1 time unit to permit blood vessels to rest; wherein the recovery period temporarily stops the continually repeating cycle; and operating in real time to affect presentation of the streaming video content, wherein the image parameter value is selected from a group consisting of a brightness, a contrast, a saturation, a sharpness, a resolution, and any combination thereof. ### Claim 10 (depends on 9) The method of claim 9 further includes applying a dichoptic presentation to each eye of a user to treat eye conditions. ### Claim 11 (depends on 9) The method of claim 9, wherein the pre-programmed stimulation regime further includes introducing a flicker event. ### Claim 12 (depends on 9) The method of claim 9, wherein the pre-programmed stimulation regime further includes triggering an audio stimulation. ### Claim 13 (depends on 9) The method of claim 9, wherein the pre-programmed stimulation regime further includes inserting an object overlay on the streaming video content displayed on the display area. ### Claim 14 (depends on 9) The method of claim 9, wherein the pre-programmed regimen further includes modifying the display area by changing a first and a second image parameters at a frequency configured in the range of 0.5-60 Hz, wherein the modifying is configured to increase cerebral blood flow in a user's brain in comparison to a method lacking the modifying; and wherein the modifying is further configured to alter a level of the first and the second image parameters within a range of 99% to +99% of the visibly noticeable intensity of the streaming video content. ### Claim 15 (depends on 9) The method of claim 9, wherein the display device is configured for a dichoptic presentation selected from a group consisting of a Side by Side, a Frame Sequential, a Field Sequential presentation, and any combination thereof. ### Claim 16 A medical device system to increase cerebral blood flow by using an unconventional pre-programmed visual stimulator, comprising: a head mountable visual display device having a display area and coupled to a controller unit, the controller unit configured to alter presentation of a video image in a streaming video content in real time for presenting the video image to each eye of a user in accordance with a pre-programmed stimulation regime; a data storage device for storing the pre-programmed stimulation regime that is identical for different patients; an audio device configured to provide an audio stimulation according to the pre-programmed stimulation regime; wherein the audio device, the data storage device, the head mountable visual display device are connected to the controller unit; the pre-determined stimulation regime further including at least one visibly noticed intensity alteration of an image parameter defining the video image presented on the at least one display area; and wherein, the controller unit is further configured to: alter a level of an intensity of an image parameter value at a frequency in a range of 0.5-60 Hz for the streaming video content in a continually repeating cycle, the cycle having a crest and a trough as compared to a baseline intensity; activate a recovery period of less than or equal to 1 time unit to permit blood vessels to rest; and recover by temporarily stopping the continually repeating cycle; and operate in real time to affect presentation of the streaming video content, wherein the image parameter value is selected from a group consisting of a brightness, a contrast, a saturation, a sharpness, a resolution, and any combination thereof.