Bodipy dyes for biological imaging
AssigneeThe General Hospital Corporation
InventorsRalph Mazitschek, Alexandra M. Courtis, James Adam Hendricks
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Abstract
This invention relates to water-soluble mono-alkoxy and mono-alkyne BODIPY derivatives, including methods for making the same. For examples, provided herein are compounds of Formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein: (a) is a BODIPY ligand system; X is a halogen; L is absent or a linker; and Z is selected from the group consisting of: a group reactive with a biologically active molecule and a detectable agent.
Claims8
A compound of Formula (I):
- wherein:
- is a BODIPY ligand system;
- X is 18F or 19F;
- L is absent or a linker;
- and
- Z is selected from the group consisting of:
- a group reactive with a biologically active molecule and a detectable agent;
- wherein the moiety O-L-Z is selected from the group consisting of:
- wherein n and m are independently an integer from 1 to 20;
- and
- p is an integer from 0 to 20.
A compound of Formula (II):
- wherein:
- is a BODIPY ligand system;
- X is 18F or 19F;
- L is absent or a linker;
- and
- Z is selected from the group consisting of:
- a group reactive with a biologically active molecule and a detectable agent;
- wherein the moiety (C2)-L-Z is selected from the group consisting of:
- wherein n and m are each independently an integer from 1 to 20, and p is an integer from 0 to 20.
A compound selected from the group consisting of:
- wherein the F bound to B is 18F or 19F.
A compound selected from the group consisting of:
- wherein the F bound to B is 18F or 19F.
A compound of Formula (III):
- wherein:
- is a BODIPY ligand system selected from the group consisting of:
- X is 18F or 19F;
- and
- R1 is selected from the group consisting of:
- a substituted or unsubstituted C1-20 alkyl, substituted or unsubstituted C1-20 alkoxy, or substituted or unsubstituted C1-20 alkynyl.
A compound of Formula (VII):
- wherein:
- is a BODIPY ligand system;
- and
- each L-Z is
Dependencies are inferred from the claim text.