Trabecular meshwork stem cells
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsYiqin Du, James L. Funderburgh, Joel Steven Schuman
Life of this patent
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Abstract
Provided herein are isolated populations of multipotent stem cells capable of differentiating into trabecular meshwork (TM) cells, methods of obtaining an isolated population of TM cells, and isolated populations of TM cells obtained therefrom. Compositions, kits, and devices comprising the isolated populations of multipotent stem cells or TM cells are also provided herein. Further provided are methods of using the compositions, kits, and devices for decreasing intraocular pressure in an eye, increasing cell density in a trabecular meshwork of an eye, increasing outflow of aqueous humor from an eye, or treating or preventing a medical condition in a subject.
Claims15
A method of decreasing intraocular pressure in an eye, comprising administering into an eye of a subject in need thereof a composition comprising a therapeutic amount of an isolated population of multipotent stem cells and a pharmaceutically acceptable carrier, diluent, or excipient;
- wherein the administered multipotent stem cells differentiate, in the eye, into trabecular meshwork cells and thereby increase cell density in the trabecular meshwork and decrease the intraocular pressure in the eye.
A method of increasing cell density in a trabecular meshwork (TM) of an eye, comprising administering into an eye of a subject in need thereof a therapeutic amount of a composition comprising an isolated population of multipotent stem cells;
- wherein the administered multipotent stem cells differentiate, in the eye, into trabecular meshwork cells and thereby increase cell density in the TM.
A method of increasing outflow of aqueous humor from an eye, comprising administering into an eye of a subject in need thereof a therapeutic amount of a composition comprising an isolated population of multipotent stem cells and a pharmaceutically acceptable carrier, diluent, or excipient;
- wherein the administered multipotent stem cells differentiate, in the eye, into trabecular meshwork cells and thereby increase cell density in the trabecular meshwork and increase the outflow of aqueous humor.
Dependencies are inferred from the claim text.